骨质疏松症
骨水泥
材料科学
骨愈合
间充质干细胞
生物医学工程
水泥
化学
医学
内科学
外科
复合材料
病理
作者
Lei Huang,Peihao Cai,Mengxuan Bian,Jieqin Yu,Lan Xiao,Shunyi Lu,Jiayi Wang,Weisin Chen,Guanjie Han,Xingdong Xiang,Xin Liu,Libo Jiang,Changsheng Liu,Jian Zhang
标识
DOI:10.1016/j.mtbio.2024.101092
摘要
Osteoporosis (OP) can result in slower bone regeneration than the normal condition due to the imbalance between osteogenesis and osteoclastogenesis, making osteoporotic bone defects healing a significant clinical challenge. Calcium phosphate cement (CPC) is a promising bone substitute material due to its good osteoinductive activity, however, the drawbacks such as fragility, slow degradation rate and incapability to control bone loss restrict its application in osteoporotic bone defects treatment. Currently, we developed the PLGA electrospun nanofiber sheets to carry alendronate (ALN) and magnesium oxide nanoparticle (nMgO) into CPC, therefore, to obtain a high-strength bone cement (C/AM-PL/C). The C/AM-PL/C bone cement had high mechanical strength, anti-washout ability, good injection performance and drug sustained release capacity. More importantly, the C/AM-PL/C cement promoted the osteogenic differentiation of bone marrow mesenchymal stem cells and neovascularization via the release of Mg
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