Research progress of sirtuins in renal and cardiovascular diseases

自噬 白藜芦醇 烟酰胺腺嘌呤二核苷酸 氧化应激 医学 生物 生物信息学 药理学 NAD+激酶 内科学 生物化学 细胞凋亡
作者
Wanning Wang,Jia Li,Lu Cai
出处
期刊:Current Opinion in Nephrology and Hypertension [Ovid Technologies (Wolters Kluwer)]
卷期号:30 (1): 108-114 被引量:5
标识
DOI:10.1097/mnh.0000000000000660
摘要

Sirtuins are a family of nicotinamide adenine dinucleotide+-dependent enzymes catalyzing target protein deacetylation to modulate cellular metabolism, response to oxidative stress and inflammation, senescence, autophagy and apoptosis. In this review, we provide an overview of recent studies regarding the alterations and roles of sirtuins in a variety of renal and cardiovascular diseases. We are also going to highlight activators and inhibitors of sirtuins in the prevention of these diseases. This will help us to understand how this field may change in the future.Recent studies have elucidated how physical or diseased conditions alter the expressions and enzyme activity of sirtuins and expounded sexual differences in sirtuins functions. In addition, interventions by targeting sirtuins have been applied in preclinical and clinical studies to prevent or slow the development of related diseases.The advantages of female sex in renal and cardiovascular diseases are partially due to the expression and function of sirtuins. Estrogen activates sirtuins and in turn sirtuins promote estrogen receptor signaling. In addition, the hypoglycemic agents, sodium-glucose cotransporter 2 inhibitors protect against diabetic nephropathy at least in part via activating SIRT-1. Although several compounds targeted sirtuins are promising drug candidates in a variety of renal and cardiovascular diseases, well designed large clinical trials are still required to identify their efficacy and safety.

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