一致性
医学
细胞学
淋巴
淋巴结
罗斯(数学)
病态的
诊断准确性
放射科
病理
核医学
内科学
几何学
数学
作者
Umang Shah,Arpan Shah,Chandrakant M. Shah,Udayan Kachchhi,Hetal V. Shah,Palak U. Shah
标识
DOI:10.1183/13993003.congress-2020.2852
摘要
Patients with Mediastinal Lymphadenopathy or Nodal Mass undergoing EBUS TBNA for diagnosis, decisions are based on rapid on-site evaluation (ROSE) findings. We aimed to analyze the clinical utility of Toluidine blue staining on EBUS TBNA samples and concordance rate between ROSE diagnosis and final HPE diagnosis. Methods: Diagnosis concordance was defined as cases where lymph nodes (LNs) presented the same diagnosis in ROSE and final diagnosis. The smear submitted for ROSE was stained using toluidine blue stain. The diagnosis and specimen adequacy in ROSE was compared with that of the final cytology report. Results: 320 patients were included and 1537 lymph nodes samples. ROSE diagnosis was concordant with final diagnosis in 1486 (96.68%) LNs and non-concordant in 51 (3.31%). Unsatisfactory ROSE diagnosis was more likely to be non-concordant (82.8 vs 17.1%) than a ROSE satisfactory diagnosis (97.4 vs 2.3%) or normal node diagnosis (98.1 vs 1.9%) (P < .0001). The sensitivity, specificity, NPV, PPV, and overall accuracy of ROSE were 0.84, 0.98, 0.97, 0.98, and 0.97, respectively. Differences in diagnosis concordance rate between pathologist (P < .023), cell block preparations (P < .03), number of passes and TBNA slides were seen. Conclusions: TBNA slides stained with Toluidine blue will give us cyto pathological diagnosis in less than 1 sec of microscopic examination which will diminish complications and helps to obtain adequate tissue rapidly in critically ill - hypoxic patient. ROSE diagnosis has a high concordance with the final diagnosis, reducing procedure time and optimizing sample for molecular profiling.
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