A Review of Different Analytical Techniques: Bumetanide

Bumetanide [1] (C 17 H 20 N 2 O 5 S) chemically known as 3-butylamino-4-phenoxy-5-sulfamoylbenzoic acid, is an antiepileptic drug.Bumetanide (Figure 1) is synthesized from 4-chlorobenzoic acid (Mo.Wt. 364.417g/mol).It is used to treat oedema due to heart failure, liver failure, or kidney problems and high blood pressure.Bumetanide acts by blocking NKCC1 cation-chloride co-transporter and in turn reduced chloride concentration in neurons of brain.This leads to more hyperpolarization activity by GABA, useful for treatment of neonatal seizures.