自噬
内皮干细胞
细胞生物学
炎症
氧化应激
程序性细胞死亡
医学
生物
免疫学
细胞凋亡
内科学
生物化学
体外
出处
期刊:Int J Endocrinol Metab
日期:2018-03-20
卷期号:38 (2): 113-116
标识
DOI:10.3760/cma.j.issn.1673-4157.2018.02.011
摘要
Autophagy, a self-protecting response of eukaryotic cells, has important physiological functions. There is few research about autophagy during the course of diabetic vasculopathy and the protective effect of autophagy on vascular endothelial cell injury.It has been indicated that the basis of autophagy in endothelial cell is a survival mechanism in diabetes, while autophagy can protect cells from excessive stimulation, especially in the case of high glucose, hyperinsulinemia, hyperlipidemia, oxidative stress and inflammation. However, excessive autophagy can damage endothelial cells, leading to autophagic death of cells. Therefore, a comprehensive study of the characteristics and mechanisms of autophagy in endothelial cells under different conditions might provide novel strategies for the prevention and treatment of diabetes and its vascular complications.
Key words:
Vascular endothelial cell; Autophagy; Diabetic vascular disease
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