第1周
DNA损伤
G2-M DNA损伤检查点
细胞周期检查点
支票1
DNA修复
细胞周期
细胞生物学
癌症研究
检查点激酶2
激酶
癌症
生物
DNA
细胞周期蛋白依赖激酶1
遗传学
作者
Hannah L. Smith,Harriet Southgate,Deborah A. Tweddle,Nicola J. Curtin
出处
期刊:Expert Reviews in Molecular Medicine
[Cambridge University Press]
日期:2020-01-01
卷期号:22
被引量:194
摘要
Abstract DNA damage response (DDR) pathway prevents high level endogenous and environmental DNA damage being replicated and passed on to the next generation of cells via an orchestrated and integrated network of cell cycle checkpoint signalling and DNA repair pathways. Depending on the type of damage, and where in the cell cycle it occurs different pathways are involved, with the ATM-CHK2-p53 pathway controlling the G1 checkpoint or ATR-CHK1-Wee1 pathway controlling the S and G2/M checkpoints. Loss of G1 checkpoint control is common in cancer through TP53, ATM mutations, Rb loss or cyclin E overexpression, providing a stronger rationale for targeting the S/G2 checkpoints. This review will focus on the ATM-CHK2-p53-p21 pathway and the ATR-CHK1-WEE1 pathway and ongoing efforts to target these pathways for patient benefit.
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