A Nanopore Array of Individual Addressability Enabled by Integrating Microfluidics and a Multiplexer

Solid-state nanopores (SSN) are of significant potential as a versatile tool for chemical sensing, biomolecule inspection, nanoparticle detection, etc. High throughput characterization of SSN in an arrayed format is highly desired for a wide range of applications. Herein, we demonstrate a novel design to integrate an SSN array with microfluidics and a multiplexer. Ionic current measurement on each nanopore can then be individually addressed fluidically and/or electrically with minimum cross talk (electric leakage). This integration provides a scalable platform for automated high-throughput, low-cost, and rapid electrical characterization potentially of a large number of SSN.