Accuracy of liver and spleen stiffness on magnetic resonance elastography for detecting portal hypertension: a systematic review and meta-analysis

医学 磁共振弹性成像 磁共振成像 门脉高压 弹性成像 置信区间 食管静脉曲张 荟萃分析 脾脏 放射科 胃肠病学 内科学 超声波 肝硬化
作者
Ranjit Singh,Mitchell P. Wilson,Prayash Katlariwala,M. Hassan Murad,Matthew D. F. McInnes,Gavin Low
出处
期刊:European Journal of Gastroenterology & Hepatology [Lippincott Williams & Wilkins]
卷期号:32 (2): 237-245 被引量:35
标识
DOI:10.1097/meg.0000000000001724
摘要

Introduction The purpose of this systematic review and meta-analysis was to evaluate the diagnostic accuracy of liver and spleen stiffness on magnetic resonance elastography (MRE) for detecting clinically significant portal hypertension. Methods A systematic review of MEDLINE, EMBASE, Scopus, the Cochrane Library, and the Grey Literature through to 15 August 2019 was performed. Original articles with >10 patients evaluating liver and/or spleen stiffness on MRE using a reference standard of portal hypertension defined as intractable ascites, esophageal varices, encephalopathy and/or death were included in analysis. Patient, clinical, MRI, and diagnostic performance was independently acquired by two reviewers. Meta-analysis was performed using a bivariate mixed-effects regression model. Results Fourteen studies were included with 12 studies evaluating liver stiffness and eight studies evaluating spleen stiffness. The pooled and weighted sensitivity, specificity, and area under the curve (AUC) values for liver stiffness on MRE were 83% [95% confidence interval (CI) 72–90%], 80% (95% CI 70–88%), and 88% (95% CI 85–91%), respectively. The pooled and weighted sensitivity, specificity, and AUC values for spleen stiffness on MRE were 79% (95% CI 61–90%), 90% (95% CI 80–95%), and 92% (95% CI 89–94%), respectively. The liver and spleen stiffness sensitivity and specificity values were comparable when evaluating for esophageal varices only at of 80% (95% CI 66–89%) and 76% (95% CI 62–86%) for liver stiffness, and 75% (95% CI 52–90%) and 89% (95% CI 70–96%) for spleen stiffness. Discussion Liver and spleen stiffness on MRE can serve as a supplemental noninvasive assessment tools for detecting clinically significant portal hypertension. Spleen stiffness may be more specific and accurate than liver stiffness for detecting portal hypertension.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
松鼠桂鱼发布了新的文献求助10
1秒前
zkk完成签到,获得积分10
2秒前
赘婿应助整齐的芷雪采纳,获得10
2秒前
Persist发布了新的文献求助10
3秒前
量子星尘发布了新的文献求助10
4秒前
朱博完成签到,获得积分10
4秒前
Su73完成签到,获得积分10
4秒前
4秒前
麻麻薯完成签到 ,获得积分10
5秒前
没有蛀牙发布了新的文献求助10
5秒前
NJSGSKL完成签到,获得积分20
6秒前
科研狗完成签到 ,获得积分10
8秒前
gar发布了新的文献求助10
8秒前
nenoaowu发布了新的文献求助10
9秒前
欣慰的海豚完成签到,获得积分10
9秒前
可爱的函函应助自然卷采纳,获得10
11秒前
爆米花应助安详的冷安采纳,获得10
11秒前
11秒前
胡说八道完成签到 ,获得积分10
15秒前
15秒前
积极觅海发布了新的文献求助10
16秒前
17秒前
海的海完成签到 ,获得积分10
18秒前
舒心的南珍完成签到,获得积分10
18秒前
20秒前
20秒前
20秒前
畅跑daily完成签到,获得积分10
20秒前
风云完成签到,获得积分10
21秒前
赖晨靓发布了新的文献求助10
22秒前
22秒前
风云发布了新的文献求助10
25秒前
要减肥发布了新的文献求助10
25秒前
zyn发布了新的文献求助10
25秒前
Lucas应助NJSGSKL采纳,获得10
27秒前
29秒前
传奇3应助WangXiaoze采纳,获得10
30秒前
小蘑菇应助科研通管家采纳,获得30
30秒前
Owen应助科研通管家采纳,获得10
30秒前
研友_VZG7GZ应助科研通管家采纳,获得10
30秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976253
求助须知:如何正确求助?哪些是违规求助? 3520405
关于积分的说明 11203301
捐赠科研通 3257028
什么是DOI,文献DOI怎么找? 1798589
邀请新用户注册赠送积分活动 877755
科研通“疑难数据库(出版商)”最低求助积分说明 806521