小鼠肝炎病毒
病毒学
病毒
毒力
严重联合免疫缺陷
肝炎
生物
免疫学
鼻腔给药
免疫缺陷
乙型肝炎病毒
医学
疾病
病理
免疫系统
体内
传染病(医学专业)
2019年冠状病毒病(COVID-19)
生物技术
基因
生物化学
作者
Huang Ds,Emancipator Sn,Fletcher Dr,Lamm Me,Mazanec Mb
出处
期刊:PubMed
日期:1996-04-01
卷期号:46 (2): 167-73
被引量:10
摘要
Mouse hepatitis virus (MHV) is a pervasive pathogen that causes morbidity and mortality in mouse colonies worldwide. Although it is not a major cause of mortality in immunocompetent mice, infections from MHV strains of lower virulence can be fatal to athymic nude mice. The histopathologic features and alterations of serum biochemical parameters resulting from infection with a low-virulence MHV strain in severe combined immunodeficiency (scid) mice has not been well described. Thus we recently studied the disease caused by MHV-S in scid mice after intranasal inoculation. Mouse hepatitis virus infection in scid mice, which have severe defects of B and T cells, may be highly lethal, resulting in immediate mortality. However, our results indicate that scid mice survived for an average of 12 to 14 days after infection with doses of MHV up to 10(7) PFU/mouse. The virus caused a significant increase in serum enzyme activities and bilirubin concentration associated with histologically demonstrable hepatocellular injury at postinoculation days 3, 4, and 8. Furthermore, virus was detected in mouse liver homogenates and nasal and bronchial lavage specimens. These results provide valuable information regarding the histopathologic and biochemical consequences of MHV-S infection in scid mice.
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