埃尔特罗姆博帕格
医学
血小板生成素
皮疹
再生障碍性贫血
罗米普洛斯蒂姆
毒性
皮肤病科
血小板生成素受体
不利影响
耐火材料(行星科学)
丙型肝炎
胃肠病学
内科学
免疫性血小板减少症
骨髓
血小板
造血
物理
天体生物学
生物
遗传学
干细胞
作者
Tiana Kazemi,Sabrina Martín,Scott Worswick
摘要
Eltrombopag is a thrombopoietin mimetic used for the treatment of thrombocytopenia in patients with chronic immune thrombocytopenia, hepatitis C patients undergoing antiviral therapy, and thrombocytopenia secondary to aplastic anemia that is refractory to immunosuppressive therapy. We report a case of a 25-year-old man with a history of aplastic anemia who presented with fever and a monomorphic papular rash. Subsequent labs, biopsy, and clinical course favored drug-induced cutaneous toxicity, with eltrombopag as the likely culprit. Eltrombopag is generally well-tolerated; however, clinicians should be aware of the possibility of dose-independent drug-induced cutaneous toxicity with this medication. This report reviews the mechanism and use of eltrombopag along with a summary of associated adverse cutaneous reactions.
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