医学
强直性脊柱炎
血沉
髓样
巴斯菲
内科学
免疫学
C反应蛋白
受体
脊柱炎
巴斯代人
调解人
髓系细胞
疾病
炎症
胃肠病学
银屑病性关节炎
作者
Chun Hsiung Chen,Hsien‐Tzung Liao,Hung-An Chen,Toong-Hua Liang,Chin-Tien Wang,Chung Tei Chou
出处
期刊:PubMed
日期:2008-09-01
卷期号:35 (9): 1846-8
被引量:17
摘要
To investigate the possible role of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in ankylosing spondylitis (AS).Serum sTREM-1 levels were measured in 80 patients with AS and 30 healthy controls, and synovial fluid (SF) sTREM-1 levels were tested in 6 AS patients using ELISA. Demographic data were collected, and patient's disease activity (BASDAI), functional ability (BASFI), and global assessment (BAS-G) were evaluated. We also tested erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and IgA in these patients.Serum sTREM-1 levels were detectable (definition, > or = 15 pg/ml) in 31.3% (25/80) of the AS patients, as compared to only 10% (3/30) of healthy controls (p = 0.027). SF sTREM-1 levels were detectable (> or = 15 pg/ml) in 83% (5/6) of the AS patients. The detectable rate of sTREM-1 in SF was significantly higher than in serum (p = 0.018). Disease duration was shorter in AS patients with "higher" serum sTREM-1 levels (> or = 30 pg/ml) versus those with "lower" levels (< 30 pg/ml) [mean (SD), 4.3 (3.7) vs 8.6 (7.8) yrs, p = 0.036], but the differences between these 2 groups of patients were not evident based on results of BASDAI, BASFI, BAS-G, ESR, CRP, or IgA levels. Of note, serum sTREM-1 levels inversely correlated with disease duration (r = -0.433, p = 0.03) in the 25 AS patients with detectable sTREM-1 levels.sTREM-1 seems to be a new mediator involved in patients with AS, particularly in the early stages of disease.
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