日本脑炎
中国大陆
病毒学
病毒
脑炎
传输(电信)
中国
载体(分子生物学)
病毒性脑炎
死亡率
基因型
分布(数学)
生物
医学
地理
基因
重组DNA
生物化学
电气工程
考古
工程类
内科学
数学分析
数学
作者
Yayun Zheng,Minghua Li,Huanyu Wang,Guodong Liang
摘要
SUMMARY Japanese encephalitis (JE), caused by Japanese encephalitis virus (JEV) infection, is the most important viral encephalitis in the world. Approximately 35,000–50,000 people suffer from JE every year, with a mortality rate of 10,000–15,000 people per year. Although the safety and efficacy of JE vaccines (inactivated and attenuated) have been demonstrated, China still accounts for 50% of the reported JE cases worldwide. In this review, we provide information about the burden of JE in mainland China and the corresponding epidemiology from 1949 to 2010, including the morbidity and mortality of JE; the age, gender, and vocational distribution of JE cases; its regional and seasonal distribution; and JE immunization. In addition, we discuss the relationships among vectors, hosts, and JEV isolates from mainland China; the dominant vector species for JEV transmission; the variety of JEV genotypes and the different biological characteristics of the different JEV genotypes; and the molecular evolution of JEV. Copyright © 2012 John Wiley & Sons, Ltd.
科研通智能强力驱动
Strongly Powered by AbleSci AI