链脲佐菌素
糖尿病
医学
胰岛素
内科学
1型糖尿病
内分泌学
作者
Kenneth K. Wu,Youming Huan
标识
DOI:10.1002/0471141755.ph0547s40
摘要
Streptozotocin (STZ) is an antibiotic that can cause pancreatic β-cell destruction, so it is widely used experimentally as an agent capable of inducing insulin-dependent diabetes mellitus (IDDM), also known as type 1 diabetes mellitus (T1DM). This unit describes protocols for the production of insulin deficiency and hyperglycemia in mice and rats, using STZ. These models for diabetes can be employed for assessing the mechanisms of T1DM, screening potential therapies for the treatment of this condition, and evaluation of therapeutic options.
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