存储单元
生物
CD8型
免疫学
慢性感染
病毒学
记忆T细胞
细胞毒性T细胞
T细胞
病毒
抗原
丙型肝炎病毒
效应器
免疫系统
遗传学
体外
晶体管
量子力学
电压
物理
作者
Maike Hofmann,Dominik Wieland,Hanspeter Pircher,Robert Thimme
摘要
Summary Memory CD 8 + T cells are essential in orchestrating protection from re‐infection. Hallmarks of virus‐specific memory CD 8 + T cells are the capacity to mount recall responses with rapid induction of effector cell function and antigen‐independent survival. Growing evidence reveals that even chronic infection does not preclude virus‐specific CD 8 + T‐cell memory formation. However, whether this kind of CD 8 + T‐cell memory that is established during chronic infection is indeed functional and provides protection from re‐infection is still unclear. Human chronic hepatitis C virus infection represents a unique model system to study virus‐specific CD 8 + T‐cell memory formation during and after cessation of persisting antigen stimulation.
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