安普克
免疫系统
炎症
蛋白激酶A
AMP活化蛋白激酶
信号转导
机制(生物学)
生物
细胞生物学
免疫学
激酶
癌症研究
哲学
认识论
作者
Jing Wang,Zhenyu Li,Li Gao,Yanshuang Qi,Haibo Zhu,Xuemei Qin
标识
DOI:10.1007/s11427-017-9169-6
摘要
AMP-activated protein kinase (AMPK) is a sensor of cellular energy status that plays a key role in energetic metabolism regulation. Metabolic changes in immune cells, such as dendritic cell (DC), macrophages, neutrophils and lymphocytes that participate in the signal directed programs that promote or inhibit immune mediated diseases, including cancer, atherosclerosis and inflammatory diseases. Multiple pathogenic mechanisms are involved in the initiation and progression of disease, and many pathways have been uncovered. The mechanistic overlap in the metabolic changes and inflammation could indicate that some of the targets they have are in common, whereas AMPK could be useful in treatment of both disorders. The insight into identification of AMPK responsible for specific immune regulation, anti-inflammatory actions and understanding of the underlying molecular mechanism will promote the generation of novel AMPK activators, and provide novel therapy strategy.
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