化学
反应性(心理学)
组合化学
有机合成
对映选择合成
有机化学
催化作用
纳米技术
医学
病理
材料科学
替代医学
作者
Kate Lauder,Anita Toscani,Nicolò Scalacci,Daniele Castagnolo
出处
期刊:Chemical Reviews
[American Chemical Society]
日期:2017-11-22
卷期号:117 (24): 14091-14200
被引量:375
标识
DOI:10.1021/acs.chemrev.7b00343
摘要
Propargylamines are a versatile class of compounds which find broad application in many fields of chemistry.This review aims to describe the different strategies developed so far for the synthesis of propargylamines and their derivatives as well as to highlight their reactivity and use as building blocks in the synthesis of chemically relevant organic compounds.In the first part of the review, the different synthetic approaches to synthesize propargylamines, such as A 3 couplings and C-H functionalization of alkynes, have been described and organized on the basis of the catalysts employed in the syntheses.Both racemic and enantioselective approaches have been reported.In the second part, an overview of the transformations of propargylamines into heterocyclic compounds such as pyrroles, pyridines, thiazoles and oxazoles, as well as other relevant organic derivatives, is presented.
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