Bilirubin acts as a multipotent guardian of cardiovascular integrity: more than just a radical idea

胆红素 医学 氧化应激 内科学 心脏病学 内分泌学 免疫学
作者
Andrew C. Bulmer,Bhavisha Bakrania,Eugene F. du Toit,Ai‐Ching Boon,Paul J. Clark,Lawrie W. Powell,Karl‐Heinz Wagner,John P. Headrick
出处
期刊:American Journal of Physiology-heart and Circulatory Physiology [American Physical Society]
卷期号:315 (3): H429-H447 被引量:59
标识
DOI:10.1152/ajpheart.00417.2017
摘要

Bilirubin, a potentially toxic catabolite of heme and indicator of hepatobiliary insufficiency, exhibits potent cardiac and vascular protective properties. Individuals with Gilbert’s syndrome (GS) may experience hyperbilirubinemia in response to stressors including reduced hepatic bilirubin excretion/increased red blood cell breakdown, with individuals usually informed by their clinician that their condition is of little consequence. However, GS appears to protect from all-cause mortality, with progressively elevated total bilirubin associated with protection from ischemic heart and chronic obstructive pulmonary diseases. Bilirubin may protect against these diseases and associated mortality by reducing circulating cholesterol, oxidative lipid/protein modifications, and blood pressure. In addition, bilirubin inhibits platelet activation and protects the heart from ischemia-reperfusion injury. These effects attenuate multiple stages of the atherosclerotic process in addition to protecting the heart during resultant ischemic stress, likely underpinning the profound reduction in cardiovascular mortality in hyperbilirubinemic GS. This review outlines our current knowledge of and uses for bilirubin in clinical medicine and summarizes recent progress in revealing the physiological importance of this poorly understood molecule. We believe that this review will be of significant interest to clinicians, medical researchers, and individuals who have GS.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
小锋完成签到 ,获得积分10
刚刚
Elsa完成签到,获得积分10
刚刚
刚刚
cindy发布了新的文献求助10
刚刚
IvanMcRae应助张萌采纳,获得10
刚刚
Davy_Y完成签到,获得积分10
1秒前
量子星尘发布了新的文献求助10
1秒前
2秒前
快乐的小天鹅完成签到,获得积分10
2秒前
Jason发布了新的文献求助10
2秒前
3秒前
万能图书馆应助小李采纳,获得10
5秒前
bofu发布了新的文献求助10
6秒前
小张完成签到,获得积分10
7秒前
柯一一应助淡淡夕阳采纳,获得10
7秒前
7秒前
CHL5722发布了新的文献求助20
7秒前
石斑鱼完成签到,获得积分10
8秒前
酷酷完成签到,获得积分10
9秒前
wf关注了科研通微信公众号
9秒前
Bdcy完成签到 ,获得积分10
10秒前
深情安青应助奋斗的俊驰采纳,获得10
10秒前
11秒前
阔达的惠完成签到,获得积分10
11秒前
bofu发布了新的文献求助30
11秒前
12秒前
13秒前
13秒前
孤独的嫣给孤独的嫣的求助进行了留言
15秒前
orixero应助背后的小白菜采纳,获得10
15秒前
领导范儿应助陈某人采纳,获得10
16秒前
理性悲歌发布了新的文献求助10
16秒前
17秒前
bofu发布了新的文献求助30
17秒前
17秒前
700w完成签到 ,获得积分0
18秒前
18秒前
YXH发布了新的文献求助10
19秒前
20秒前
21秒前
高分求助中
The Mother of All Tableaux Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 2400
Ophthalmic Equipment Market by Devices(surgical: vitreorentinal,IOLs,OVDs,contact lens,RGP lens,backflush,diagnostic&monitoring:OCT,actorefractor,keratometer,tonometer,ophthalmoscpe,OVD), End User,Buying Criteria-Global Forecast to2029 2000
Optimal Transport: A Comprehensive Introduction to Modeling, Analysis, Simulation, Applications 800
Official Methods of Analysis of AOAC INTERNATIONAL 600
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 588
T/CIET 1202-2025 可吸收再生氧化纤维素止血材料 500
Interpretation of Mass Spectra, Fourth Edition 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3956295
求助须知:如何正确求助?哪些是违规求助? 3502477
关于积分的说明 11107954
捐赠科研通 3233164
什么是DOI,文献DOI怎么找? 1787196
邀请新用户注册赠送积分活动 870506
科研通“疑难数据库(出版商)”最低求助积分说明 802105