化学
刀豆蛋白A
IC50型
吲哚试验
立体化学
脂多糖
抑制性突触后电位
粳稻
消炎药
体外
生物化学
药理学
植物
生物
免疫学
神经科学
作者
Tao Feng,Kai-Ting Duan,Shijun He,Bin Wu,Yongsheng Zheng,Hong‐Lian Ai,Zheng-Hui Li,Juan He,Jianping Zuo,Ji‐Kai Liu
出处
期刊:Organic Letters
[American Chemical Society]
日期:2018-12-10
卷期号:20 (24): 7926-7928
被引量:34
标识
DOI:10.1021/acs.orglett.8b03489
摘要
Two monoterpenoid indole alkaloids, ophiorrhines A (1) and B (2), were obtained from plant Ophiorrhiza japonica BI. Their structures were elucidated by extensive spectroscopic methods and single crystal X-ray diffraction. Compounds 1 and 2 possess a novel spirocyclic ring system. Its biosynthesis pathway is proposed. Compound 2 exhibits potent inhibitory activity against concanavalin A (Con A) induced T cell proliferation and lipopolysaccharide (LPS) induced B lymphocyte cell proliferation with IC50 values 13.3 and 7.5 μM, respectively. Compound 1 exhibits significant inhibition specifically against the LPS-induced proliferation of B lymphocyte cells with IC50 value 18.6 μM.
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