毛螺菌科
细菌
微生物学
脂多糖
H&E染色
生物
肠道菌群
肠道通透性
粪便
势垒函数
拟杆菌
染色
免疫学
16S核糖体RNA
厚壁菌
细胞生物学
遗传学
作者
Yuanyuan Xie,Wen‐Jun Li,Limeng Zhu,Shixiang Zhai,Song Qin,Zhenning Du
摘要
Abstract The health‐promoting effects of phycocyanin (PC) have become widely accepted over the last two decades. In this study, we investigated the effects of different doses of PC in modulating the intestinal microbiota and the intestinal barrier in mice. Six‐week‐old male C57BL/6 mice were treated with PC for 28 days. Fecal samples were collected before and after PC intervention, and the microbiota were analyzed by 16S rRNA high‐throughput sequencing. Bacterial abundance and diversity increased after PC intervention. Saccharolytic bacteria of the families Lachnospiraceae and Ruminococcaceae, which can produce butyric acid, increased after PC treatment. The family Rikenellaceae, which contains hydrogen‐producing bacteria, also increased after PC intervention. The PC treatment reduced intestinal permeability and increased the intestinal barrier function, as demonstrated by hematoxylin–eosin staining and reduced serum lipopolysaccharide levels. The modulating effects on the intestinal microbiota were more favorable in the low‐dose PC group.
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