再生医学
仿生材料
计算机科学
材料科学
药物输送
仿生学
生物加工
制作
纳米技术
组织工程
生物医学工程
工程类
医学
生物
干细胞
病理
遗传学
替代医学
作者
Pooyan Makvandi,Aziz Maleki,Majid Shabani,Aaron R. J. Hutton,Melissa Kirkby,Rezvan Jamaledin,Tianxu Fang,Jiahuan He,Jesse Lee,Barbara Mazzolai,Ryan F. Donnelly,Franklin R. Tay,Guojun Chen,Virgilio Mattoli
出处
期刊:Matter
[Elsevier]
日期:2022-02-01
卷期号:5 (2): 390-429
被引量:66
标识
DOI:10.1016/j.matt.2021.11.021
摘要
Summary
Nature contains abundant systems that can significantly alter their structures and properties to adapt to the surrounding environment. Through natural selection and unceasing evolution, hierarchical architectures and sophisticated strategies have been created by nature to achieve optimally adapted materials for biomedical applications. The development of microneedles (MNs) has advanced to the next generation of bioinspired MNs (BMNs), with the goal of improving functions such as amelioration of mechanical properties and tissue adhesion. The biomimetic designs and structures of MNs are highlighted in the present review. This is followed by an in-depth discussion of the fabrication approaches from molding techniques to 3D and 4D printing. The medical applications of BMNs, including drug delivery, regenerative medicine, biopsy sampling, and biosensing, are also discussed. Last, future opportunities and challenges with respect to clinical translation are also deliberated.
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