冷冲击域
生物发生
生物
翻译(生物学)
RNA结合蛋白
细胞生物学
蛋白质家族
转录因子
核糖体生物发生
基因
信使核糖核酸
遗传学
计算生物学
核糖核酸
核糖体
出处
期刊:Biokhimiya
[Springer Nature]
日期:2022-01-01
卷期号:87 (S1): S5-S19
被引量:5
标识
DOI:10.1134/s0006297922140024
摘要
Y-box binding protein 1 is a member of the cold shock domain (CSD) protein family and one of the most studied proteins associated with a large number of human diseases. This review aims to critically reassess the growing number of pathological functions ascribed to YB-1 in the past decades. The focus is given on the important role of YB-1 and related CSD proteins in the physiology of normal cells. The functional significance of these proteins is highlighted by their high evolutionary conservation from bacteria to men, where they are ubiquitously expressed and involved in coordinating all steps of mRNA biogenesis, including transcription, translation, storage, and degradation. Their activities are especially important under conditions requiring rapid change in the gene expression programs, such as early embryonic development, differentiation, stress, and adaptation to new environments. Therefore, to define a precise role of YB-1 in tumorigenic transformation and in other pathological conditions, it is important to understand its basic properties and functions in normal cells, and how they are interrupted in complex diseases including cancer.
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