氧化应激
炎症
抗抑郁药
信号转导
医学
萧条(经济学)
多酚
MAPK/ERK通路
发病机制
药理学
生物
免疫学
内科学
精神科
抗氧化剂
细胞生物学
生物化学
焦虑
宏观经济学
经济
作者
Tapan Behl,Tarapati Rana,Ghallab Alotaibi,Md. Shamsuzzaman,Maaz Naqvi,Aayush Sehgal,Sukhbir Singh,Neelam Sharma,Yosif Almoshari,Ahmed A. H. Abdellatif,Muhammad Shahid Iqbal,Saurabh Bhatia,Ahmed Al‐Harrasi,Simona Bungău
标识
DOI:10.1016/j.biopha.2021.112545
摘要
Depression is one of the most debilitating psychiatric disorders affecting people of all ages worldwide. Despite significant heterogeneity between studies, increased inflammation and oxidative stress have been found in depression. Oxidative stress and inflammation are involved in the pathogenesis of depression. In the current review, we discussed the markers of oxidative stress and inflammation in depressive disorder and the association between these markers and the antidepressant treatment. The role of natural polyphenols in regulating various cell signaling pathways related to oxidative stress and inflammation has also been reviewed. The inhibitory effect of polyphenols on several cell signaling pathways reveals the vital role of polyphenols in the prevention and treatment of depressive disorder. Understanding the mechanism of polyphenols implicated in the regulation of cell signaling pathways is essential for the identification of lead compounds and the development of novel effective compounds for the prevention and treatment of depressive disorder.
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