亲脂性
生物膜
金黄色葡萄球菌
环丙沙星
程序性细胞死亡
化学
活性氧
微生物学
毒性
细菌
体内
生物物理学
抗生素
抗菌剂
生物化学
生物
有机化学
细胞凋亡
生物技术
遗传学
作者
Nalin Abeydeera,Bing Yu,Bishnu D. Pant,Min‐Ho Kim,Songping D. Huang
出处
期刊:Biomaterials Science
[The Royal Society of Chemistry]
日期:2021-12-07
卷期号:10 (2): 474-484
被引量:9
摘要
Iron is essential for all forms of life including pathogenic bacteria. However, iron is also a double-edged sword in biology, as increase of iron uptake can result in reactive oxygen species (ROS)-triggered cell death from the iron-catalyzed Fenton reaction. In this study, we demonstrate that iron-hinokitiol, Fe(hinok)3, a neutral Fe(III) complex formed with the naturally occurring metal chelator hinokitiol; (2-hydroxy-4-isopropyl-2,4,6-cycloheptatrien-1-one) can harness the clear ability, due to its high lipophilicity and the nonpolar nature, to penetrate the cell membrane of Staphylococcus aureus (SA) and exhibit potent antimicrobial activity that is enhanced by approximately 10 000 times as compared with hinokitiol itself. Additionally, this Fe(III) complex shows a strong ability to inhibit biofilm formation. More importantly, the development of resistance in SA toward this complex is considerably hampered in comparison with that toward ciprofloxacin. The in vivo evaluation of antimicrobial efficacy in the murine model of skin wound infection by SA confirms that the treatment with a single dose of this complex can reduce the bacterial burden by 83%, demonstrating the therapeutic potential of Fe(hinok)3 in treating skin and soft tissue infections.
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