光动力疗法
转移
癌症治疗
癌症
光敏剂
癌症治疗
纳米技术
化学
医学
内科学
材料科学
有机化学
作者
Chen Chen,Changsong Wu,Jiming Yu,Xiaohui Zhu,Yihan Wu,Jinliang Liu,Yong Zhang
标识
DOI:10.1016/j.ccr.2022.214495
摘要
In recent years, the wide application of photodynamic therapy (PDT) in the field of biomedicine has proved its significance in cancer treatment. A variety of nanomaterials are employed in PDT to transfer the received energy to photosensitizer for the generation of toxic singlet oxygen (1O2) to eliminate cancer cells, which has advantages of tissue specificity, non-invasiveness, and low toxicity. However, the low penetration of the light source, the hypoxia of the tumor microenvironment (TME), and the metastasis and recurrence of tumor cells severely limit the therapeutic effect of PDT. In this review, the design of PDT platforms used for oncotherapy is presented, starting with the principle of PDT. Additionally, this review discusses the latest studies of PDT-based combinatorial cancer therapy strategies in the process of tumor treatment, aiming to evaluate the potential of PDT in future clinical cancer treatments. Specifically, the latest progress of using combination therapy strategies to improve PDT’s main deficiencies in three aspects are reviewed: i) combined with a few drugs or gases to overcome hypoxic TME, ii) employing advanced light sources to increase penetration depth, iii) combined with immunotherapy (IT) to inhibit tumor metastasis, which are the three most widely adopted combinatorial cancer therapies to improve the defects of PDT to optimize the treatment effect. Based on the above, an imaging-guided therapeutic nanoplatform integrating diagnosis and treatment has brought more optimized treatment effects to PDT. Finally, current challenges and prospects regarding these promising combinatorial cancer therapies are discussed. With a great deal of recent technological improvements, PDT is becoming a revolutionary development in the field of cancer medicine and the backbone of many emerging combination therapies.
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