The Metabolic Syndrome as a Predictor of Nonalcoholic Fatty Liver Disease

医学 非酒精性脂肪肝 代谢综合征 内科学 国家胆固醇教育计划 脂肪肝 血脂异常 体质指数 前瞻性队列研究 腹部肥胖 优势比 全国健康与营养检查调查 肝病 疾病 肥胖 生理学 人口 环境卫生
作者
Masahide Hamaguchi,Takao Kojima,Noriyuki Takeda,Takayuki Nakagawa,Hiroya Taniguchi,Kimio Fujii,Tatsushi Omatsu,Tomoaki Nakajima,H Sarui,Makoto Shimazaki,Takahiro Kato,Junichi Okuda,Kazunori Ida
出处
期刊:Annals of Internal Medicine [American College of Physicians]
卷期号:143 (10): 722-722 被引量:1022
标识
DOI:10.7326/0003-4819-143-10-200511150-00009
摘要

The frequent association of nonalcoholic fatty liver disease with components of the metabolic syndrome such as obesity, hyperglycemia, dyslipidemia, and hypertension is well known. However, no prospective study has examined the role of the metabolic syndrome in the development of this disease.To characterize the longitudinal relationship between the metabolic syndrome and nonalcoholic fatty liver disease.A prospective observational study.A medical health checkup program in a general hospital.4401 apparently healthy Japanese men and women, 21 to 80 years of age, with a mean body mass index (BMI) of 22.6 kg/m2 (SD, 3.0).Alcohol intake was assessed by using a questionnaire. Biochemical tests for liver and metabolic function and abdominal ultrasonography were done. Modified criteria of the National Cholesterol Education Program Adult Treatment Panel III were used to characterize the metabolic syndrome.At baseline, 812 of 4401 (18%) participants had nonalcoholic fatty liver disease. During the mean follow-up period of 414 days (SD, 128), the authors observed 308 new cases (10%) of nonalcoholic fatty liver disease among 3147 participants who were disease-free at baseline and who completed a second examination. Regression of nonalcoholic fatty liver disease was found in 113 (16%) of 704 participants who had the disease at baseline and who completed a second examination. Men and women who met the criteria for the metabolic syndrome at baseline were more likely to develop the disease during follow-up (adjusted odds ratio, 4.00 [95% CI, 2.63 to 6.08] and 11.20 [CI, 4.85 to 25.87], respectively). Nonalcoholic fatty liver disease was less likely to regress in those participants with the metabolic syndrome at baseline.Ultrasonography may lead to an incorrect diagnosis of nonalcoholic fatty liver disease in 10% to 30% of cases and cannot distinguish steatohepatitis from simple steatosis. Self-reported alcohol intake may cause bias. Because all of the participants were Japanese, generalizability to non-Japanese populations is uncertain.The metabolic syndrome is a strong predictor of nonalcoholic fatty liver disease.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
优雅的绿蓉完成签到 ,获得积分10
刚刚
SciGPT应助怕黑海冬采纳,获得10
刚刚
充电宝应助pgg采纳,获得10
刚刚
研友_nxer7Z发布了新的文献求助10
2秒前
冷艳惜梦关注了科研通微信公众号
3秒前
3秒前
zzz完成签到,获得积分10
3秒前
等于几都行完成签到 ,获得积分10
4秒前
5秒前
6秒前
maitiandehe发布了新的文献求助10
7秒前
鱼儿吐泡泡完成签到,获得积分10
9秒前
甲壳虫完成签到 ,获得积分10
9秒前
10秒前
科研通AI5应助科研通管家采纳,获得10
10秒前
科研通AI5应助科研通管家采纳,获得10
10秒前
NexusExplorer应助科研通管家采纳,获得10
10秒前
科研通AI5应助科研通管家采纳,获得10
10秒前
大个应助科研通管家采纳,获得10
11秒前
qikkk应助科研通管家采纳,获得10
11秒前
11秒前
Piper关注了科研通微信公众号
11秒前
11秒前
11秒前
脑洞疼应助科研通管家采纳,获得10
11秒前
12秒前
科研猫完成签到,获得积分10
13秒前
13秒前
今后应助遥远采纳,获得30
13秒前
激昂的逊发布了新的文献求助10
14秒前
李爱国应助ixueyi采纳,获得10
14秒前
秀丽誉完成签到,获得积分10
15秒前
15秒前
16秒前
17秒前
hanatae完成签到,获得积分10
17秒前
WDD完成签到,获得积分10
18秒前
张慧完成签到,获得积分10
19秒前
秀丽誉发布了新的文献求助10
19秒前
可爱的函函应助Elody采纳,获得30
20秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976418
求助须知:如何正确求助?哪些是违规求助? 3520512
关于积分的说明 11203586
捐赠科研通 3257127
什么是DOI,文献DOI怎么找? 1798594
邀请新用户注册赠送积分活动 877804
科研通“疑难数据库(出版商)”最低求助积分说明 806523