Doxorubicin‐Loaded Magnetic Silk Fibroin Nanoparticles for Targeted Therapy of Multidrug‐Resistant Cancer

Advanced MaterialsVolume 26, Issue 43 p. 7393-7398 Communication Doxorubicin-Loaded Magnetic Silk Fibroin Nanoparticles for Targeted Therapy of Multidrug-Resistant Cancer Ye Tian, Ye Tian State Key Laboratory of Molecular, Engineering of Polymers, Department of Macromolecular Science, and Laboratory of Advanced Materials, Fudan University, Shanghai, 200433 P. R. ChinaSearch for more papers by this authorXuejiao Jiang, Xuejiao Jiang State Key Laboratory of Molecular, Engineering of Polymers, Department of Macromolecular Science, and Laboratory of Advanced Materials, Fudan University, Shanghai, 200433 P. R. ChinaSearch for more papers by this authorXin Chen, Corresponding Author Xin Chen State Key Laboratory of Molecular, Engineering of Polymers, Department of Macromolecular Science, and Laboratory of Advanced Materials, Fudan University, Shanghai, 200433 P. R. ChinaE-mail: [email protected], [email protected]Search for more papers by this authorZhengzhong Shao, Zhengzhong Shao State Key Laboratory of Molecular, Engineering of Polymers, Department of Macromolecular Science, and Laboratory of Advanced Materials, Fudan University, Shanghai, 200433 P. R. ChinaSearch for more papers by this authorWuli Yang, Corresponding Author Wuli Yang State Key Laboratory of Molecular, Engineering of Polymers, Department of Macromolecular Science, and Laboratory of Advanced Materials, Fudan University, Shanghai, 200433 P. R. ChinaE-mail: [email protected], [email protected]Search for more papers by this author Ye Tian, Ye Tian State Key Laboratory of Molecular, Engineering of Polymers, Department of Macromolecular Science, and Laboratory of Advanced Materials, Fudan University, Shanghai, 200433 P. R. ChinaSearch for more papers by this authorXuejiao Jiang, Xuejiao Jiang State Key Laboratory of Molecular, Engineering of Polymers, Department of Macromolecular Science, and Laboratory of Advanced Materials, Fudan University, Shanghai, 200433 P. R. ChinaSearch for more papers by this authorXin Chen, Corresponding Author Xin Chen State Key Laboratory of Molecular, Engineering of Polymers, Department of Macromolecular Science, and Laboratory of Advanced Materials, Fudan University, Shanghai, 200433 P. R. ChinaE-mail: [email protected], [email protected]Search for more papers by this authorZhengzhong Shao, Zhengzhong Shao State Key Laboratory of Molecular, Engineering of Polymers, Department of Macromolecular Science, and Laboratory of Advanced Materials, Fudan University, Shanghai, 200433 P. R. ChinaSearch for more papers by this authorWuli Yang, Corresponding Author Wuli Yang State Key Laboratory of Molecular, Engineering of Polymers, Department of Macromolecular Science, and Laboratory of Advanced Materials, Fudan University, Shanghai, 200433 P. R. ChinaE-mail: [email protected], [email protected]Search for more papers by this author First published: 19 September 2014 https://doi.org/10.1002/adma.201403562Citations: 192Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract A strategy to prepare doxorubicin-loaded magnetic silk fibroin nanoparticles is presented. The nanoparticles serve as a nanometer-scale drug-delivery system in the chemotherapy of multidrug-resistant cancer under the guidance of a magnetic field. The magnetic tumor-targeting ability broadens the range of biomedical applications of silk fibroin, and the nanoparticle-assisted preparation strategy is useful for the advancement of other biomacromolecule-based materials. Citing Literature Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Filename Description adma201403562-sup-0001-S1.pdf1 MB Supplementary Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume26, Issue43November 19, 2014Pages 7393-7398 RelatedInformation