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Immunophenotype of adult and childhood acute promyelocytic leukaemia: correlation with morphology, type of PML gene breakpoint and clinical outcome. A cooperative Italian study on 196 cases

免疫分型 断点 医学 形态学(生物学) 表型 基因 生物 遗传学 免疫学 染色体易位 流式细胞术
作者
Cesare Guglielmi,Maria Paola Martelli,Daniela Diverio,Susanna Fenu,M. L. Vegna,A Cantù-Rajnoldi,Andrea Biondi,Maria Grazia Cocito,Luigi Del Vecchio,Antonio Tabilio,Giuseppe Avvisati,Giuseppe Basso,Francesco Lo‐Coco
出处
期刊:British Journal of Haematology [Wiley]
卷期号:102 (4): 1035-1041 被引量:196
标识
DOI:10.1046/j.1365-2141.1998.00871.x
摘要

Acute promyelocytic leukaemia (APL), characterized by a specific PML‐RARα fusion gene resulting from translocation t(15;17) and by a high response rate to differentiation therapy with all‐ trans retinoic acid, presents clinical (varying WBC counts, age and treatment outcome), morphological (hypergranular M3 and hypogranular M3V) and molecular (three isoforms of PML breakpoint) heterogeneity. We correlated leukaemic immunophenotype with these aspects in 196 molecularly confirmed APLs (63 children and 133 adults) in Italy. The bcr3 isoform ( P = 0.05) and FAB M3V ( P = 0.05) were more frequent in children. We confirmed in APL an immunophenotype characterized by frequent expression of CD13, CD33 and CD9 and rare expression of HLA‐DR, CD10, CD7 and CD11b. However, we recognized CD2 in 28%, CD34 in 23% and CD19 in 11% of cases and demonstrated by double labelling that CD34 and CD2 may be co‐expressed. CD2, CD34 and CD19 were significantly intercorrelated, and variably associated to other features: CD2 and CD34 with PML bcr3 ( P < 0.001 and P < 0.001, respectively) and with M3V ( P < 0.001 and P = 0.002), whereas only CD19 was directly correlated with WBC counts and only CD2 positively influenced CR rate (logistic model) and event‐free survival (Cox model). We conclude that immunophenotype plays a role in the determination of the biological and clinical heterogeneity of childhood and adult APL.

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