依那普利
昆普利尔
西拉普利
内科学
医学
心脏病学
赖诺普利
血管紧张素转换酶
血流动力学
卡托普利
血管紧张素转换酶抑制剂
左心室肥大
血压
血浆肾素活性
肾素-血管紧张素系统
作者
Edward D. Fröhlich,Shigeo Horinaka
出处
期刊:Hypertension
[Ovid Technologies (Wolters Kluwer)]
日期:1991-10-01
卷期号:18 (4_supplement)
被引量:32
标识
DOI:10.1161/01.hyp.18.4_suppl.ii2
摘要
The effects of six angiotensin converting enzyme inhibitors (captopril, CGS-16617, cilazapril, enalapril, utibapril, and quinapril) on cardiovascular structure, systemic hemodynamics, left ventricular end-diastolic pressure, left ventricular pumping ability, and aortic distensibility were assessed in male normotensive Wistar-Kyoto and spontaneously hypertensive rats 16-19 weeks of age. Rats (10 in each group) were treated for 3 weeks with drugs or control diluents administered daily by gavage. The agents, in general, had similar hemodynamic effects, although these effects on cardiac mass were variable; some agents reduced left ventricular mass and some produced no change. These effects occurred in hypertrophied as well as nonhypertrophied chambers. Furthermore, changes in left ventricular pumping ability were not necessarily related to the ability of these agents to change left ventricular mass; this dissociation in performance was neither related to change in structure nor to changes in aortic distensibility. Thus, even within a same class of antihypertensive agents (i.e., angiotensin converting enzyme inhibitors), similarly induced hemodynamic alterations were associated with inconsistent changes in left ventricular pumping ability or aortic distensibility regardless of whether the structure was hypertrophied before therapy. These dissociated responses in cardiovascular structure and function may be related to pharmacodynamic or pharmacokinetic differences; alternatively, they also may be related to these differences in action on local myocytic renin-angiotensin systems or in intramyocytic biological responses.
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