默认模式网络
心理学
任务(项目管理)
调制(音乐)
认知心理学
功能连接
神经科学
物理
声学
经济
管理
作者
Baojuan Li,Xiang Wang,Shuqiao Yao,Dewen Hu,Karl Friston
标识
DOI:10.3389/fpsyg.2012.00206
摘要
The default mode network (DMN) has recently attracted widespread interest. Previous studies have found that task-related processing can induce deactivation and changes in the functional connectivity of this network. However, it remains unclear how tasks modulate the underlying effective connectivity within the DMN. Using recent advances in dynamic causal modeling (DCM), we investigated the modulatory effect of (gender judgment) task performance on directed connectivity within the DMN. Sixteen healthy subjects were scanned twice: at rest and while performing a gender judgment task. Group independent component analysis was used to identify independent spatial components. Four subject-specific regions of interest (ROIs) were defined according to the ensuing default mode component: the posterior cingulate cortex, the left lateral parietal cortex, the right lateral parietal cortex, and the medial prefrontal cortex. Effective connectivity among these regions was then characterized with stochastic DCM, revealing enhanced (extrinsic) between region connectivity within the DMN during task sessions - and a universal decrease in (intrinsic) self-inhibition - relative to resting sessions. These results suggest a distributed but systematic modulatory effect of cognitive and attentional set on the effective connectivity subtending the DMN: an effect that increases its sensitivity to inputs and may optimize distributed processing during task performance.
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