端粒酶
体细胞
端粒
生物
癌症
癌症研究
端粒酶逆转录酶
癌细胞
分子生物学
病理
遗传学
DNA
医学
基因
作者
Nam W. Kim,Mieczyslaw A. Piatyszek,Karen R. Prowse,Calvin B. Harley,Michael D. West,Peter L. C. Ho,Gina M. Coviello,Woodring E. Wright,Scott L. Weinrich,Jerry W. Shay
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1994-12-23
卷期号:266 (5193): 2011-2015
被引量:6980
标识
DOI:10.1126/science.7605428
摘要
Synthesis of DNA at chromosome ends by telomerase may be necessary for indefinite proliferation of human cells. A highly sensitive assay for measuring telomerase activity was developed. In cultured cells representing 18 different human tissues, 98 of 100 immortal and none of 22 mortal populations were positive for telomerase. Similarly, 90 of 101 biopsies representing 12 human tumor types and none of 50 normal somatic tissues were positive. Normal ovaries and testes were positive, but benign tumors such as fibroids were negative. Thus, telomerase appears to be stringently repressed in normal human somatic tissues but reactivated in cancer, where immortal cells are likely required to maintain tumor growth.
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