聚乙二醇化
PEG比率
试剂
高分子
组合化学
肽
小分子
分子
聚合物
溶剂
材料科学
化学
有机化学
聚乙二醇
生物化学
经济
财务
出处
期刊:Biomaterials
[Elsevier]
日期:2001-03-01
卷期号:22 (5): 405-417
被引量:991
标识
DOI:10.1016/s0142-9612(00)00193-9
摘要
The paper discusses general problems in using PEG for conjugation to high or low molecular weight molecules. Methods of binding PEG to different functional groups in macromolecules is reported together with their eventual limitations. Problems encountered in conjugation, such as the evaluation of the number of PEG chains bound, the localisation of the site of conjugation in polypeptides and the procedure to direct PEGylation to the desired site in the molecule are discussed. Finally, the paper reports on more specific methods regarding reversible PEGylation, cross-linking reagents with PEG arms, PEG for enzyme solubilization in organic solvent and new polymers as alternative to PEG.
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