化学
核糖核酸
磷酰胺
寡核苷酸
固相合成
组合化学
纳米技术
生物化学
DNA
基因
材料科学
肽
作者
Sabine Müller,Jörn Wolf,Sergei A. Ivanov
出处
期刊:Current Organic Synthesis
[Bentham Science]
日期:2004-07-01
卷期号:1 (3): 293-307
被引量:50
标识
DOI:10.2174/1570179043366675
摘要
The biological potential of RNA along with the variety of possible applications has led to an increased demand for large-scale production of RNA molecules. Recent developments in the field allow for the synthesis of long RNA molecules (up to 100 nts) of excellent quality. This review focuses on current strategies (i.e. 2-O-TBDMS, 2-O-TOM and 2-O-ACE chemistry) for chemical RNA synthesis. Keywords: oligonucleotides, phosphoramidite, protecting groups, rna, solid phase, synthesis
科研通智能强力驱动
Strongly Powered by AbleSci AI