炎症
心脏纤维化
再生医学
疾病
平衡
医学
神经科学
病态的
免疫疗法
纤维化
生物
生物信息学
免疫学
干细胞
免疫系统
病理
细胞生物学
内科学
作者
Eldad Tzahor,Stefanie Dimmeler
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2022-09-02
卷期号:377 (6610)
被引量:34
标识
DOI:10.1126/science.abm4443
摘要
Heart regenerative medicine has been gradually evolving from a view of the heart as a nonregenerative organ with terminally differentiated cardiac muscle cells. Understanding the biology of the heart during homeostasis and in response to injuries has led to the realization that cellular communication between all cardiac cell types holds great promise for treatments. Indeed, recent studies highlight new disease-reversion concepts in addition to cardiomyocyte renewal, such as matrix- and vascular-targeted therapies, and immunotherapy with a focus on inflammation and fibrosis. In this review, we will discuss the cross-talk within the cardiac microenvironment and how specific therapies aim to target the hostile cardiac milieu under pathological conditions.
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