Nickel‐Catalyzed Asymmetric CH Functionalization

Due to its unique nature and distinctive reactivity, nickel has been widely used as catalyst in CH bond functionalization. However, enantioselective versions have been faced with great challenge owing to the lack of efficient chiral ligands. With the emergence of new types of chiral ligands such as bifunctional phosphine oxides and bulky N-heterocyclic carbenes (NHC) bearing chiral pendants, substantial progress has been achieved in recent years. Herein, we summarize recent advances of this burgeoning field.