Assessment of Cardiovascular Disease Among Predominantly Black Gout Patients

医学 痛风 内科学 血脂异常 优势比 心脏病学 冠状动脉疾病 心肌梗塞 人口 糖尿病 体质指数 置信区间 冲程(发动机) 外科 疾病 内分泌学 工程类 环境卫生 机械工程
作者
Harshith Chandrakumar,Anoop Venkat Puskoor,Seeta Chillumuntala,Sara Sharif,Diego Mora,Tanuj Gupta,Ashkan Tadayoni,Seyedeh Leila Zonnoor,Pelin Çeliker,Stephanie C. Yakoubovitch,Andrew Tsai,Courtney Chiu,Anan Kazi,Michael Freilich,Ahmad Saleh,Seung Jae Moon,Kingsley Cruickshank,Shuojohn Li,Julie Katz,Joanna Eichler,Louis Salciccioli,Isabel M McFarlane
出处
期刊:Jcr-journal of Clinical Rheumatology [Lippincott Williams & Wilkins]
被引量:1
标识
DOI:10.1097/rhu.0000000000001948
摘要

Although the association between gout and cardiovascular disease (CVD) has been extensively studied, scarce data are available for the Black population. We aimed to assess the association between gout and CVD in a predominantly Black urban population with gout.A cross-sectional analysis was performed between a gout cohort and an age-/sex-matched control group. Clinical parameters and 2D echocardiograms were reviewed for the patients with gout and heart failure (HF). The primary outcome studied includes the prevalence and strength of association between gout and CVD. Secondary outcomes studied includes strength of association of gout and HF categorized by ejection fraction, mortality, and HF readmissions.Four hundred seventy-one patients with gout had a mean age of 63.7 ± 0.5 years; 89% were Black, 63% were men, and mean body mass index was 31.3 ± 0.4 kg/m 2 . Hypertension, diabetes mellitus, and dyslipidemia were present in 89%, 46%, and 52%, respectively. Compared with controls, patients with gout had significantly higher rates of angina, arrhythmia, coronary artery disease/stents, myocardial infarction, coronary artery bypass graft surgery, cerebrovascular accident, and peripheral vascular disease. The adjusted odds ratio for CVD was 2.9 (95% confidence interval, 1.9-4.5; p < 0.001). Gout patients had a higher prevalence of HF with 45% (n = 212) compared with controls with 9.4% (n = 44). Adjusted odds ratio for HF risk was 7.1 (95% confidence interval, 4.7-10.6; p < 0.01).Gout in a predominantly Black population confers 3 times the CVD risk and 7 times HF-specific risk compared with age- and sex-matched cohort. Further research is needed to confirm our findings and to develop interventions to reduce morbidity associated with gout.
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