Fenton/Fenton-like microreactor in inflammatory microenvironment: Photothermal enhanced catalytic oxidation strategy for chemodynamic treatment of rheumatoid arthritis

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by joint hypoxia and the proliferation of M1 macrophages. Therefore, relieving hypoxia and removing M1 macrophages will be a new direction in the treatment of RA. Folic acid (FA)-loaded PCP nanoparticles Fe-Co prussian blue analogue@CeO2@PDA (F-PCP) were used for in situ oxygen (O2) production/chemodynamic/photothermal/treatment of RA. On one hand, PDA-mediated photothermal therapy also has a certain effect on the removal of proliferative M1 macrophages. On the other hand, under the irradiation of NIR laser, F-PCP has obtained excellent photothermal therapy (PTT) performance, which accelerates the Fenton/Fenton-like reaction to produce reactive oxygen species and O2, so as to achieve the chemodynamic therapy (CDT) that inhibits the proliferation of M1 macrophages. It is worth noting that the RA was improved by the synergistic action of CDT and PTT, and the generation of oxygen can alleviate RA hypoxia, which is a means to improve CDT. Therefore, the F-PCP NPs show great potential in improving the therapeutic effect of RA.