醛固酮
医学
原发性醛固酮增多症
病理生理学
疾病
高血压的病理生理学
激素
平衡
生物信息学
内科学
血压
生物
作者
Ross D. Feldman,Rohan Sanjanwala,Raj Padwal,Alexander A. C. Leung
标识
DOI:10.1016/j.cjca.2023.08.035
摘要
Abstract
Aldosterone was initially identified as a hormone primarily related to regulation of fluid and electrolyte homeostasis. However, over the past 20 years there has been an increasing appreciation of its role in regulation of vascular function and pathophysiology in the setting of hypertension, atherosclerosis, and heart failure. This review highlights recent advances in our understanding the biology of aldosterone as it relates to the pathophysiology and the management of vascular disease—especially related to hypertension. The review focuses on 3 key areas: 1) advances in our understanding of the cellular mechanisms by which aldosterone mediates its cellular effects, 2) identification of the hidden epidemic of aldosteronism as a mediator of hypertension, and 3) appreciating new therapeutic advances in the clinical pharmacology of aldosterone inhibition in cardiovascular and renal disease.
科研通智能强力驱动
Strongly Powered by AbleSci AI