FLG Knockdown–Related Skin–Lung Crosstalk Biologically Underpins a Filaggrin-Related Childhood Asthma Subtype

The existence of a sequence of comorbidities in childhood—the atopic march—is a matter of debate (Belgrave et al, 2014), and this controversy remains in part because the mechanisms driving these diseases are complex and multifactorial. The work by Graff et al (2023) may therefore be a valuable addition to the field, presenting novel findings to enhance our understanding of the biology of skin–lung crosstalk (Figure 1). Such crosstalk could play a critical role in the progression from FLG-related atopic dermatitis (AD) to asthma in childhood.