Abnormal Progenitor Cell Differentiation and Cardiomyocyte Proliferation in Hypoplastic Right Heart Syndrome

HomeCirculationVol. 149, No. 11Abnormal Progenitor Cell Differentiation and Cardiomyocyte Proliferation in Hypoplastic Right Heart Syndrome No AccessResearch ArticleRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessResearch ArticleRequest AccessFull TextAbnormal Progenitor Cell Differentiation and Cardiomyocyte Proliferation in Hypoplastic Right Heart Syndrome Yang Yu, Cankun Wang, Shiqiao Ye, Zhaohui Xu, Hui Lin, Karen Texter, Vasudha Shukla, Samir Ghadiali, Qin Ma, Vidu Garg and Ming-Tao Zhao Yang YuYang Yu https://orcid.org/0000-0001-6885-019X Center for Cardiovascular Research (Y.Y., S.Y., H.L., V.G., M.-T.Z.), Nationwide Children's Hospital, Columbus, OH. Abigail Wexner Research Institute, The Heart Center (Y.Y., S.Y., H.L., K.T., V.G., M.-T.Z.), Nationwide Children's Hospital, Columbus, OH. , Cankun WangCankun Wang https://orcid.org/0000-0002-0225-9855 Department of Biomedical Informatics (C.W., Q.M.), The Ohio State University College of Medicine, Columbus, OH. , Shiqiao YeShiqiao Ye Center for Cardiovascular Research (Y.Y., S.Y., H.L., V.G., M.-T.Z.), Nationwide Children's Hospital, Columbus, OH. Abigail Wexner Research Institute, The Heart Center (Y.Y., S.Y., H.L., K.T., V.G., M.-T.Z.), Nationwide Children's Hospital, Columbus, OH. , Zhaohui XuZhaohui Xu https://orcid.org/0000-0003-0645-1737 Center for Vaccines and Immunity (Z.X.), Nationwide Children's Hospital, Columbus, OH. Department of Pediatrics (Z.X., K.T., V.G., M.-T.Z.), The Ohio State University College of Medicine, Columbus, OH. , Hui LinHui Lin Center for Cardiovascular Research (Y.Y., S.Y., H.L., V.G., M.-T.Z.), Nationwide Children's Hospital, Columbus, OH. Abigail Wexner Research Institute, The Heart Center (Y.Y., S.Y., H.L., K.T., V.G., M.-T.Z.), Nationwide Children's Hospital, Columbus, OH. , Karen TexterKaren Texter Abigail Wexner Research Institute, The Heart Center (Y.Y., S.Y., H.L., K.T., V.G., M.-T.Z.), Nationwide Children's Hospital, Columbus, OH. Department of Pediatrics (Z.X., K.T., V.G., M.-T.Z.), The Ohio State University College of Medicine, Columbus, OH. , Vasudha ShuklaVasudha Shukla Department of Biomedical Engineering, The Ohio State University College of Engineering, Columbus, OH (V.S., S.G.). , Samir GhadialiSamir Ghadiali https://orcid.org/0000-0002-6845-774X Department of Biomedical Engineering, The Ohio State University College of Engineering, Columbus, OH (V.S., S.G.). Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH (S.G., V.G., M.-T.Z.). , Qin MaQin Ma https://orcid.org/0000-0002-3264-8392 Department of Biomedical Informatics (C.W., Q.M.), The Ohio State University College of Medicine, Columbus, OH. , Vidu GargVidu Garg https://orcid.org/0000-0002-3778-5927 Center for Cardiovascular Research (Y.Y., S.Y., H.L., V.G., M.-T.Z.), Nationwide Children's Hospital, Columbus, OH. Abigail Wexner Research Institute, The Heart Center (Y.Y., S.Y., H.L., K.T., V.G., M.-T.Z.), Nationwide Children's Hospital, Columbus, OH. Department of Pediatrics (Z.X., K.T., V.G., M.-T.Z.), The Ohio State University College of Medicine, Columbus, OH. Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH (S.G., V.G., M.-T.Z.). and Ming-Tao ZhaoMing-Tao Zhao Correspondence to: Ming-Tao Zhao, DVM, PhD, Center for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, WB4273, 575 Children's Crossroad, Columbus, OH 43215. Email E-mail Address: [email protected] https://orcid.org/0000-0002-9837-7548 Center for Cardiovascular Research (Y.Y., S.Y., H.L., V.G., M.-T.Z.), Nationwide Children's Hospital, Columbus, OH. Abigail Wexner Research Institute, The Heart Center (Y.Y., S.Y., H.L., K.T., V.G., M.-T.Z.), Nationwide Children's Hospital, Columbus, OH. Department of Pediatrics (Z.X., K.T., V.G., M.-T.Z.), The Ohio State University College of Medicine, Columbus, OH. Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH (S.G., V.G., M.-T.Z.). Originally published11 Mar 2024https://doi.org/10.1161/CIRCULATIONAHA.123.064213Circulation. 2024;149:888–891FootnotesFor Sources of Funding and Disclosures, see page 891.Circulation is available at www.ahajournals.org/journal/circCorrespondence to: Ming-Tao Zhao, DVM, PhD, Center for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, WB4273, 575 Children's Crossroad, Columbus, OH 43215. Email Mingtao.Zhao@NationwideChildrens.OrgReferences1. LaPar DJ, Bacha E. Pulmonary atresia with intact ventricular septum with borderline tricuspid valve: how small is too small.Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2019; 22:27–31. doi: 10.1053/j.pcsu.2019.02.007CrossrefMedlineGoogle Scholar2. Contreras J, Alonzo M, Ye S, Lin H, Hernandez-Rosario L, McBride KL, Texter K, Garg V, Zhao MT. Generation of an induced pluripotent stem cell line NCHi003-A from a 11-year-old male with pulmonary atresia with intact ventricular septum (PA-IVS).Stem Cell Res. 2022; 64:102893. doi: 10.1016/j.scr.2022.102893CrossrefMedlineGoogle Scholar3. Ye S, Wang C, Xu Z, Lin H, Wan X, Yu Y, Adhicary S, Zhang JZ, Zhou Y, Liu C, et al. Impaired human cardiac cell development due to NOTCH1 deficiency.Circ Res. 2023; 132:187–204. doi: 10.1161/CIRCRESAHA.122.321398LinkGoogle Scholar4. Buikema JW, Lee S, Goodyer WR, Maas RG, Chirikian O, Li G, Miao Y, Paige SL, Lee D, Wu H, et al. Wnt Activation and reduced cell-cell contact synergistically induce massive expansion of functional human iPSC-derived cardiomyocytes.Cell Stem Cell. 2020; 27:50–63.e5. doi: 10.1016/j.stem.2020.06.001CrossrefMedlineGoogle Scholar5. Puente BN, Kimura W, Muralidhar SA, Moon J, Amatruda JF, Phelps KL, Grinsfelder D, Rothermel BA, Chen R, Garcia JA, et al. The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response.Cell. 2014; 157:565–579. doi: 10.1016/j.cell.2014.03.032CrossrefMedlineGoogle Scholar eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. 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