形状记忆合金*
医学
骨骼肌
胰岛素抵抗
2型糖尿病
肌肉萎缩
人口
糖尿病
内科学
良性循环与恶性循环
2型糖尿病
肌萎缩
内分泌学
生物信息学
生物
环境卫生
组合数学
宏观经济学
经济
数学
作者
José M. López-Pedrosa,María Camprubí-Robles,Germán Guzmán-Rolo,Andres Lopez-Gonzalez,José Manuel García‐Almeida,Alejandro Sanz‐París,Ricardo Rueda
出处
期刊:Nutrients
[MDPI AG]
日期:2024-01-04
卷期号:16 (1): 172-172
被引量:18
摘要
Today, type 2 diabetes mellitus (T2DM) and skeletal muscle atrophy (SMA) have become increasingly common occurrences. Whether the onset of T2DM increases the risk of SMA or vice versa has long been under investigation. Both conditions are associated with negative changes in skeletal muscle health, which can, in turn, lead to impaired physical function, a lowered quality of life, and an increased risk of mortality. Poor nutrition can exacerbate both T2DM and SMA. T2DM and SMA are linked by a vicious cycle of events that reinforce and worsen each other. Muscle insulin resistance appears to be the pathophysiological link between T2DM and SMA. To explore this association, our review (i) compiles evidence on the clinical association between T2DM and SMA, (ii) reviews mechanisms underlying biochemical changes in the muscles of people with or at risk of T2DM and SMA, and (iii) examines how nutritional therapy and increased physical activity as muscle-targeted treatments benefit this population. Based on the evidence, we conclude that effective treatment of patients with T2DM-SMA depends on the restoration and maintenance of muscle mass. We thus propose that regular intake of key functional nutrients, along with guidance for physical activity, can help maintain euglycemia and improve muscle status in all patients with T2DM and SMA.
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