代谢物
激素
甲状腺
内科学
泌尿系统
甲状腺功能
内分泌学
甲状腺激素
化学
生理学
三碘甲状腺素
线性回归
多环芳烃
贝叶斯多元线性回归
医学
环境化学
机器学习
计算机科学
作者
Bin Zhou,Yan-Ling Deng,Qiang Zeng,Pan Yang,Xi-Jiang Hu
标识
DOI:10.1016/j.envint.2022.107698
摘要
Polycyclic aromatic hydrocarbons (PAHs) have been shown to disrupt thyroid function in toxicological studies, but epidemiological evidence is inconsistent. Furthermore, little is known on potential effects of mixtures of PAHs. This study aimed to examine the associations of exposure to PAHs as individual chemicals and mixtures with thyroid hormones. We included 378 men from a Reproductive Medicine Center in Wuhan, China. Ten monohydroxylated PAH (OH-PAH) metabolites in repeated urine specimens collected at two-time points and three thyroid hormones [thyroid-stimulating hormone (TSH), free thyroxine (FT4), and free triiodothyronine (FT3)] in one serum sample were measured. Multivariable linear regression models were applied to assess the associations between individual OH-PAH metabolites and thyroid hormones, and the associations with mixtures of OH-PAH metabolites were assessed by Bayesian kernel machine regression (BKMR) models. Multivariable linear regression models showed inverse associations between urinary 1-OHNa and TSH, between urinary 1-OHPh and 9-OHPh and FT3, as well as between urinary 2-OHPh, 3-OHPh, 9-OHPh and ∑OHPh and FT4, regardless of these individual OH-PAH metabolites modeled as continuous or tertile variables (e.g., −21.57 % in TSH; 95 % CI: −35.33 %, −4.88 % for the third vs first tertiles of 1-OHNa; p for trend = 0.014). BKMR models showed negative overall effects of all urinary OH-PAH metabolite mixtures on TSH, FT3, and FT4, and 1-OHNa, 9-OHPh, and 2-OHPh as the most important contributors, respectively, with linear inverse exposure–response associations when holding other OH-PAH metabolites at their median concentrations. Urinary OH-PAH metabolites as individual chemicals and mixtures were adversely associated with thyroid hormones among reproductive-aged men.
科研通智能强力驱动
Strongly Powered by AbleSci AI