Two new anti-inflammatory trachylobane diterpenoids from Euphorbia atoto

AbstractAbstractTwo new rare trachylobane euphoratones A-B (1-2), together with five known diterpenoids (compounds 3-7), were isolated from the aerial parts of Euphorbia atoto. Their structures were unambiguously elucidated through HRESIMS, 1D and 2D NMR spectral analysis. Compounds 1, 3, 4 and 7 showed weak anti-inflammatory activities (IC50 77.49 ± 6.34, 41.61 ± 14.49, 16.00 ± 1.71 and 33.41 ± 4.52 μM, respectively), compared to the positive control quercetin (IC50 15.23 ± 0.65 μM).Keywords: Euphorbia atotoeuphorbiaceaetrachylobane-type diterpenoidsanti-inflammatory activities AcknowledgementsThe authors are grateful to the members of the analytical group of Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences for the spectral measurements. The authors thank Dr. Y.L. Huang (Dept. of Translational Medicine; Jiangsu Hengrui Medicine Shanghai, China) for proofreading this manuscript.Disclosure statementNo potential conflict of interest was reported by the author(s).Additional informationFundingThis work was financially supported by Financial Fund of the Ministry of Agriculture and Rural Affairs, China [NFZX2021] and the China Agriculture Research System [CARS-21].