纳米颗粒
功能(生物学)
生物物理学
线粒体
纳米技术
材料科学
细胞生物学
化学
生物
作者
Xiaolan Zheng,Tianyou Wang,Jixing Gong,Xiaozhong Peng,Yulin Zhang,Yue Zhang,Nan Cao,Kaiyu Zhou,Yiwen Li,Yimin Hua,Donghui Zhang,Zhipeng Gu,Yifei Li
出处
期刊:Materials horizons
[The Royal Society of Chemistry]
日期:2024-01-01
摘要
Preservation of mitochondrial functionality is essential for heart hemostasis and cardiovascular diseases treatment. However, the current nanomedicines including liposomes, polymers and inorganic nanomaterials are severely hindered by poor stability, high manufacturing costs and potential biotoxicity. In this research, we present novel polyphenolic nanoparticles (NPs) derived from naturally occurring pomegranate peel (PP, labelled as PPP NPs), which exhibit potent antioxidative and anti-inflammatory properties, serving as a modulator of mitochondrial function. PPP NPs have been identified to improve survival rates in models of mitochondrial depletion through enhancement of cardiomyocyte proliferation and the reduction of DNA damage. Moreover, PPP NPs can effectively inhibit the production of reactive oxygen species and inflammatory mediators in lipopolysaccharide (LPS)-induced mitochondrial damage. Utilizing human engineered heart tissue and mice models, PPP NPs were found to significantly improve contractile function and alleviate inflammation activities after LPS treatment. Mechanically, PPP NPs regulated inflammatory responses
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