Greening Chromatographic Purification Processes

绿化 色谱法 化学 生物 生态学
作者
Chiara De Luca,Martina Catani,Alberto Cavazzini,Simona Felletti
出处
期刊:Royal Society of Chemistry eBooks [The Royal Society of Chemistry]
卷期号:: 373-399 被引量:1
标识
DOI:10.1039/9781837674541-00373
摘要

Biopharmaceuticals (in particular, peptides and oligonucleotides) are becoming increasingly important in therapeutic treatments, owing to their unique characteristics that cannot be replicated by conventional drugs. Their production involves an upstream step, where the target biopharmaceutical is synthesized or produced through biotechnological approaches, followed by downstream processing, in which usually single-column preparative liquid chromatography (LC) is employed to obtain the target molecules at a suitable purity for pharmaceutical applications. This step is usually the main bottleneck in terms of the sustainability of the entire process because of the large volumes of solvents employed (e.g. acetonitrile). Since in recent years there has been growing awareness of environmental issues, there is urgency to seek novel approaches to increase the greenness of the downstream processing of biopharmaceuticals. This chapter gives an overview of the latest achievements in this field, which involve not only the substitution of harmful solvents and chemicals with greener materials but also the adoption of novel approaches based on multicolumn countercurrent preparative LC. These techniques not only allow the purification process to be automated but also considerably reduce solvent consumption compared with the common single-column approaches used in industrial production.
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