已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Iron overload is positively associated with the incidence of osteoarthritis: A NHANES cross-sectional study

医学 全国健康与营养检查调查 转铁蛋白饱和度 横断面研究 肥胖 骨关节炎 内科学 铁蛋白 人口 入射(几何) 糖尿病 体质指数 逻辑回归 血清铁 内分泌学 贫血 环境卫生 血清铁蛋白 病理 替代医学 物理 光学
作者
Fei Liu
出处
期刊:Medicine [Wolters Kluwer]
卷期号:103 (43): e40089-e40089
标识
DOI:10.1097/md.0000000000040089
摘要

With the aging of the global population and the increase in the number of people with conditions such as obesity, the incidence of osteoarthritis (OA) is increasing annually. Clinical studies have shown that excessive accumulation of iron in joints is associated with age-related OA. However, there have been no reports on the relationship between iron metabolism and osteoarthritis. A STROBE-compliant cross-sectional observational study, was carried out and analyzed from the National Health and Nutrition Examination Survey from 2001 to 2020, including data on serum iron, transferrin saturation, serum ferritin, total iron-binding capacity, and transferrin receptors, as well as data on osteoarthritis. This cross-sectional study was conducted to explore the relationship between serum iron levels, osteoarthritis, and related metabolic factors. By adjusting the model and using quantile logistic regression models, the interaction between human body iron content and the aforementioned variables was analyzed. A total of 56,323 participants over 5 cycles were assessed for iron levels. After adjusting the model for age, sex, race, education level, marital status, total energy intake, physical activity, drinking, BMI, smoking, hypertension, and diabetes, we found that in different quantile regression results, serum iron was associated with OA, Q4: OR = 1.231 (95%CI: 1.009–1.501, P < .05). Ferritin is associated with OA, Q2: OR = 1.309 (95%CI: 1.012–1.692, P < .05); Q3: OR = 1.424 (95%CI: 1.129–1.797, P < .01); Q4: OR = 1.280 (95%CI: 1.013–1.616, P < .05). This cross-sectional study found that serum iron and transferrin saturation levels were positively correlated with OA incidence, suggesting that iron overload is a risk factor for OA. Large-sample prospective cohort studies are needed to confirm the correlation between iron overload and OA.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
默客完成签到,获得积分10
1秒前
2秒前
2秒前
peanut发布了新的文献求助10
2秒前
4秒前
10秒前
慕青应助123456采纳,获得10
11秒前
12秒前
hyhyhyhy发布了新的文献求助10
14秒前
Cherry发布了新的文献求助10
15秒前
16秒前
思源应助暗生崎乐采纳,获得10
16秒前
momo发布了新的文献求助10
19秒前
故意的山河完成签到,获得积分10
22秒前
夏xia完成签到 ,获得积分10
24秒前
24秒前
25秒前
PMoLGGYM2021发布了新的文献求助10
25秒前
小胜完成签到 ,获得积分10
26秒前
28秒前
29秒前
坚强枫发布了新的文献求助10
29秒前
干净的翠琴完成签到 ,获得积分10
30秒前
30秒前
快乐的寄容完成签到 ,获得积分10
30秒前
31秒前
yaling发布了新的文献求助10
32秒前
11发布了新的文献求助10
32秒前
zsc668发布了新的文献求助20
34秒前
34秒前
123456发布了新的文献求助10
35秒前
CipherSage应助xiaomu采纳,获得10
35秒前
热心市民小红花应助PANDA采纳,获得10
36秒前
37秒前
大个应助ling采纳,获得20
40秒前
tjzbw完成签到,获得积分10
40秒前
我是老大应助自由的秋灵采纳,获得10
42秒前
情怀应助momo采纳,获得10
43秒前
大方的依霜完成签到,获得积分10
43秒前
672发布了新的文献求助10
43秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989832
求助须知:如何正确求助?哪些是违规求助? 3531967
关于积分的说明 11255613
捐赠科研通 3270725
什么是DOI,文献DOI怎么找? 1805035
邀请新用户注册赠送积分活动 882181
科研通“疑难数据库(出版商)”最低求助积分说明 809208