磁共振成像
癌症治疗
肝癌
可视化
计算机科学
核磁共振
医学
放射科
癌症
人工智能
物理
内科学
作者
Gwangjun Go,Ami Yoo,Kim Tien Nguyen,Minghui Nan,Bobby Aditya Darmawan,Shirong Zheng,Byungjeon Kang,Chang‐Sei Kim,Doyeon Bang,Seonmin Lee,Kyu‐pyo Kim,Seong Soo Kang,Kyung Mi Shim,Se Eun Kim,Seungmin Bang,Deok‐Ho Kim,Jong‐Oh Park,Eunpyo Choi
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2022-11-16
卷期号:8 (46)
被引量:70
标识
DOI:10.1126/sciadv.abq8545
摘要
Microrobots that can be precisely guided to target lesions have been studied for in vivo medical applications. However, existing microrobots have challenges in vivo such as biocompatibility, biodegradability, actuation module, and intra- and postoperative imaging. This study reports microrobots visualized with real-time x-ray and magnetic resonance imaging (MRI) that can be magnetically guided to tumor feeding vessels for transcatheter liver chemoembolization in vivo. The microrobots, composed of a hydrogel-enveloped porous structure and magnetic nanoparticles, enable targeted delivery of therapeutic and imaging agents via magnetic guidance from the actuation module under real-time x-ray imaging. In addition, the microrobots can be tracked using MRI as postoperative imaging and then slowly degrade over time. The in vivo validation of microrobot system–mediated chemoembolization was demonstrated in a rat liver with a tumor model. The proposed microrobot provides an advanced medical robotic platform that can overcome the limitations of existing microrobots and current liver chemoembolization.
科研通智能强力驱动
Strongly Powered by AbleSci AI