Connecting the Innate and Adaptive Immune Responses

It is true to say that the innate and adaptive immune systems have their own distinct elements. However, it is not appropriate to view them as being completely functionally independent of one another. There is, without question, an intricate and complex relationship between the two systems that directly influences the overall nature and success of the immune response. Many other resources have provided a comprehensive coverage of the adaptive immune response, particularly in relation to the functionality of B and T cells. In this section, I shall briefly highlight some of the key processes by which the innate immune system can communicate with, influence, and affect the performance of the adaptive response. This includes by regulating transcription of major histocompatibility complex genes, by utilizing components of the complement cascade and the process of autophagy to influence B- and T-cell functions, through the action of dendritic cells and the provision of adjuvant function in the process of vaccination.