自愈水凝胶
材料科学
组织工程
生物医学工程
细胞外基质
纳米技术
再生医学
生物材料
生物相容性
再生(生物学)
去细胞化
纳米纤维
复合材料
高分子化学
工程类
作者
Hongsheng Yu,Hui Zhao,Chenyu Huang,Yanan Du
出处
期刊:ACS Biomaterials Science & Engineering
[American Chemical Society]
日期:2017-04-28
卷期号:3 (11): 3017-3021
被引量:59
标识
DOI:10.1021/acsbiomaterials.6b00620
摘要
With the development of biomimetic scaffolds for engineered cardiac constructs, a considerable number of biomaterials has been evaluated. However, in most previously reported cardiac constructs, the function of the cardiomyocytes (CMs) is restricted because of mismatches in the mechanics, conductivity, and submicrometer structure of the matrix. In this work, type I collagen hydrogels were combined with carbon nanotubes (CNTs) to assess potential improvements in hydrogel strength and conductivity and potential effects on the hydrogel structure. CMs seeded within the CNT–collagen hybrid hydrogels showed improved cardiac cell functions compared to those within pure collagen hydrogels, which suggested great promise of CNT–collagen hydrogels as functional scaffold materials for cardiac construct engineering.
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