Increased dissolution of disulfiram by dry milling with silica nanoparticles

气相二氧化硅 溶解 材料科学 粒径 差示扫描量热法 无定形固体 二硫仑 傅里叶变换红外光谱 化学工程 扫描电子显微镜 透射电子显微镜 分析化学(期刊) 化学 色谱法 有机化学 复合材料 纳米技术 热力学 物理 工程类 生物化学
作者
Guanghui Jing,Yue Zhong,Ling Zhang,Jingxin Gou,Xinchao Ji,Hao Huang,Yu Zhang,Yanjiao Wang,Haibing He,Xing Tang
出处
期刊:Drug Development and Industrial Pharmacy [Taylor & Francis]
卷期号:41 (8): 1328-1337 被引量:7
标识
DOI:10.3109/03639045.2014.949266
摘要

The purpose of this study was to find a suitable method to increase the dissolution of disulfiram (DSF) which is easily decomposed. The dissolution of DSF within 1 h was significantly increased from 37% to >90% by co-milling with Aerosil® 200 pharm (Aerosil) and the increased dissolution remained stable during long-term storage while there was no significant degradation of DSF. By monitoring the changes in particle size of the grinding mixture, a mosaic DSF-in-Aerosil structure was demonstrated. The core size of the mosaic DSF/Aerosil system was 3.625 µm. The particle size of DSF was reduced from 20.75 µm to ∼200 nm and the size of the mosaic DSF/Aerosil system (3.625∼7.956 µm) increased on increasing the drug-loading content. Differential scanning calorimetry and X-ray powder diffraction analysis confirmed the largely amorphous state of DSF in the mosaic drug/carrier system. Fourier transform infrared spectroscopy confirmed the presence of hydrogen bonding between DSF and Aerosil. Scanning electron microscopy and transmission electron microscopy verified the DSF-in-Aerosil relationship in the particle size determination at different size levels. The possible mechanisms of dry milling included the hypothesis that during impact and collision, DSF particles melted into the surface of Aerosil turning them into an amorphous state or they became inlayed into the interspaces of the Aerosil structure with a much smaller size.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
微米发布了新的文献求助10
1秒前
动人的ccc完成签到,获得积分10
1秒前
王炸完成签到,获得积分10
1秒前
Ran完成签到,获得积分20
1秒前
lovexy完成签到,获得积分10
1秒前
Meteora完成签到,获得积分10
2秒前
2秒前
qingxu发布了新的文献求助10
2秒前
Junex发布了新的文献求助10
2秒前
伍六七完成签到,获得积分10
2秒前
2秒前
wyw完成签到,获得积分10
3秒前
双孟发布了新的文献求助10
3秒前
xiaoting应助kysl采纳,获得10
3秒前
4秒前
李健的小迷弟应助自由井采纳,获得10
5秒前
klb13完成签到,获得积分0
5秒前
yy发布了新的文献求助20
5秒前
CipherSage应助syx采纳,获得10
6秒前
李健的小迷弟应助GALAXY采纳,获得10
6秒前
kaio完成签到,获得积分10
7秒前
7秒前
大鱼完成签到,获得积分20
7秒前
7秒前
xiao完成签到,获得积分10
7秒前
难过的笑天完成签到,获得积分10
7秒前
8秒前
lailai完成签到 ,获得积分10
8秒前
桐桐应助狂野怜蕾采纳,获得10
8秒前
淡定映之完成签到,获得积分20
8秒前
lynn完成签到,获得积分10
8秒前
Joff_W完成签到,获得积分10
8秒前
Jiang完成签到,获得积分10
9秒前
丘比特应助洁净斑马采纳,获得10
9秒前
xt完成签到,获得积分10
9秒前
liusx123完成签到,获得积分20
11秒前
烂漫念柏发布了新的文献求助10
11秒前
爆米花应助Lancent采纳,获得10
12秒前
12秒前
13秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 360
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3970843
求助须知:如何正确求助?哪些是违规求助? 3515550
关于积分的说明 11178897
捐赠科研通 3250660
什么是DOI,文献DOI怎么找? 1795393
邀请新用户注册赠送积分活动 875828
科研通“疑难数据库(出版商)”最低求助积分说明 805188