纳米颗粒
磁铁矿
纳米技术
磁性纳米颗粒
过氧化物酶
惰性
免疫分析
材料科学
催化作用
磁选
氧化铁纳米粒子
生物传感器
磁性纳米粒子
化学
化学工程
酶
有机化学
抗体
生物
免疫学
冶金
工程类
作者
Lizeng Gao,Jie Zhuang,Leng Nie,Jinbin Zhang,Yu Zhang,Ning Gu,Taihong Wang,Jing Feng,Dongling Yang,Sarah Perrett,Xiyun Yan
标识
DOI:10.1038/nnano.2007.260
摘要
Nanoparticles containing magnetic materials, such as magnetite (Fe3O4), are particularly useful for imaging and separation techniques. As these nanoparticles are generally considered to be biologically and chemically inert, they are typically coated with metal catalysts, antibodies or enzymes to increase their functionality as separation agents. Here, we report that magnetite nanoparticles in fact possess an intrinsic enzyme mimetic activity similar to that found in natural peroxidases, which are widely used to oxidize organic substrates in the treatment of wastewater or as detection tools. Based on this finding, we have developed a novel immunoassay in which antibody-modified magnetite nanoparticles provide three functions: capture, separation and detection. The stability, ease of production and versatility of these nanoparticles makes them a powerful tool for a wide range of potential applications in medicine, biotechnology and environmental chemistry.
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